Important structural similarities between Sho and PrPC including N-terminal repeats, a HD, endoproteolysis to a stable C1 fragment, and a C-terminal glycosylation site prefacing a GPI anchor-attachment, suggest that PrPC is an important model for deciphering the structure-to-function characteristics of Sho as it relates to the pathogenesis of prion disease in bovids [10]. Here, PRNP is linked to prion disease.