In agreement with such hypothesis, we demonstrate that H358 adenocarcinoma cells overexpressing SRSF1 acquire a more invasive phenotype as illustrated by hyperactivation of the oncogenic AKT and ERK signaling pathways, increased capacity to form colony in soft agar and acquisition of mesenchymal markers such as vimentin and N-cadherin. This evidence concerns the gene AKT1 and adenocarcinoma.