In this study, we investigated the status of SRSF1, SRSF2 and its phosphorylated form P-SRSF2, as well as of SRPK1 and SRPK2 in a series of 107 NSCLC, including 54 adenocarcinoma (ADC) and 53 squamous cell carcinoma (SCC). This evidence concerns the gene SRSF2 and adenocarcinoma.