A study conducted among 198 individuals belonging to 34 families living in Burkina Faso using the pedigree-based generalized multifactor dimensionality reduction approach, identified statistical interactions among immune genes including IL12B 3′ untranslated region, IL12Bpro, LTA+80 for mild malaria, maximum parasitemia or asymptomatic parasitemia [98] underscoring the usefulness of modeling gene-gene interaction in genetic dissection of complex diseases (Table 3). Here, IL12B is linked to malaria.