In colon cancer cells in response to the short chain fatty acid anion butyrate, the nonsteroidal anti-inflammatory drug sulindac, or the chemotherapeutic drug 5-fluorouracil, NR4A1 induces apoptosis by nuclear-cytoplasmic translocation but without direct mitochondrial targeting, although Bax is redistributed to mitochondria and induces cytochrome c release [48]. This evidence concerns the gene BAX and malignant colon neoplasm.