Although an orexigenic peptide, several studies, conclude that ghrelin has anxiogenic properties, when administered either centrally [26] or into specific sites of the brain such as the hippocampus, amygdala, dorsal raphe nucleus [19] as well as in hypothalamic nuclei, with the arcuate nucleus and the paraventricular nucleus the more sensitive regions to evoke the anxiety-like response [29]. The gene discussed is GHRL; the disease is Anxiety.