These results suggest that the genes implicated by this eQTL study may be involved downstream in a disease pathway initiated by SNCA. Interestingly, of the 18 probes showing significant modification by PD risk SNPs, the probe targeting LY6K (associated with the SNCA SNP rs2583975) was the only probe to also show significant (after Bonferroni correction) differential expression between cases and controls (p = 0.001, Table S1). Here, LY6K is linked to Parkinson disease.