TRIB2 and lung carcinoma: Our results are supported by Grandinetti's study, which demonstrated that TRIB2 is overexpressed in lung cancer through downregulation of C/EBPα [22], while upregualtion of C/EBPα in lung cancer cells results in obvious inhibition of cell proliferation, suggesting that upon TRIB2 knockdown, C/EBPα levels increase and drive lung cancer cell differentiation.