CACNA1B and nervous system disorder: We saw no decrease in neuron-specific genes classically down-regulated in neurological disorders; in fact, there was up-regulation of neuronal receptors (glutamate receptor, GABA receptor), ion channels (potassium, sodium, and hydrogen), neurotransmitter transporter (Cacna1b), and synapse-specific genes (synaptotagmin I, synaptophysin) (Supplemental Table S2), strongly supporting our contention that these analyzed cells are of neuronal origin.