We found significantly higher counts in the humanized TLR4/MD-2 and KO mice compared to WT 72 hr after infection despite the large spread in each group (median CFU for spleen, liver, and lung of 1.06×105, 1.14×105, and 1.67×103 in humanized and 1.19×106, 2.08×106, and 1.41×104 in KO vs. 2.48×103, 8.12×103, and 1.3×102 in WT, Fig. 5A). This evidence concerns the gene TLR4 and infection.