All the cells in which either component of the receptor complex was silenced exhibited an impaired capability to form tumours after injection into the liver; this effect reached statistical significance in SW-48 and HT-29 cells in which α6 integrin was silenced, and in HCT-116m, SW-48 and DLD-1 cells in which E-cadherin was silenced. Here, CDH1 is linked to neoplasm.