To evaluate a potential role for the described system in the process of liver metastasis, we first compared the capacity of HepG2 and NCI-H630 cells to adhere to grossly normal livers from CRC patients (a characterization of these cell lines in terms of CGIYRLRSC-phage binding and of α6 integrin/E-cadherin expression and coexpression is reported in Fig 1B and Fig 3C, respectively). The gene discussed is CDH1; the disease is colorectal carcinoma.