By quantitative confocal imaging, we evaluated the amounts of α6 integrin, E-cadherin and their colocalization in the following tumour settings: primary CRCs (Duke's stage IV; n = 22; Fig 9A), liver metastases from CRC (n = 100; Fig 9B), liver metastases from other cancers (n = 22; Fig 9C), and lung metastases from CRCs (n = 40; Fig 9D). This evidence concerns the gene CDH1 and colorectal carcinoma.