ANGPTL6 and colorectal carcinoma: We confirmed that normal hepatic tissues produce the highest amounts of angiopoietin-like 6, although its expression was detectable in most tissues, a result possibly related to the improved sensitivity of our staining protocol compared to the whole tissue mRNA analysis of Kim et al. Remarkably, the lung, another common site of CRC metastasis, was one of the tissues with the highest angiopoietin-like 6 levels (Fig 2).