PRNP and scrapie: Whether this imbalance is due to the loss of function (lack of prion directly or indirectly involved in dismutase activity) or the gain of new functions (aggregation of PrPSc) is still unclear, but there is evidence that the toxicity results from prion dependent processes (alteration of PrP-mediated signaling, PrP mislocalization and oligomerization) in murine models of scrapie[21].