SHBG and diabetes mellitus: After multivariable adjustment for age, family history of diabetes, smoking, physical activity, and BMI (Table3; Model 2), SHBG levels were inversely associated with diabetes among women (OR comparing the highest with the lowest quartiles, 0.13 [95% CI, 0.02–0.86]), but not among men (OR, 0.73 [95% CI, 0.38–1.40]).