Since functionally critical genes that are spatially expressed are stringently regulated by miRNAs [10], was the aim of our study to test for miRNA and SERCA2 expression in infarcted myocardium compared to corresponding remote myocardium of patients with MI, and defined by target prediction algorithms those miRNAs with a potential influence on SERCA2 mRNA 3'-UTR. This evidence concerns the gene ATP2A2 and myocardial infarction.