ITGAE and airway hyperresponsiveness: CD103+ DC have been described to express high levels of the Langerhans cell marker langerin and were increased in mice with airway hyperresponsiveness and eosinophilia suggesting a role in allergen-induced respiratory inflammation[11] With respect to adaptive T cell immunity against different pathogens, CD103+DC, CD11bhigh DC and MoDC have been identified as major migratory subsets presenting antigens in the draining lymph nodes to naïve CD4+ and CD8+ T cells[5,12-15].