HMOX1 and Abnormal intestine morphology: However, more investigations will be prerequisite whether this kind of protection with PPIs can also be ascribed to NSAIDs-induced enteropathy although there were conflicting reports, that is, one study showed PPIs can aggravate NSAIDs-induced enteropathy through dysbiosis [30], but other study showed prevention by lansoprazole of indomethacin-induced small intestinal ulceration in rats through induction of HO-1 and carbon monoxide [31].