We also showed that cisplatin can induce IL-1β secretion in NPC cells, which is in agreement with a previous study indicating that cisplatin can activate caspase-1 (Kondo et al, 1995) and accumulates in lysosomes (Safaei et al, 2005), which are the reservoir of cathepsin B (Schroder & Tschopp, 2010; Schroder et al, 2010). This evidence concerns the gene IL1B and nasopharyngeal carcinoma.