IL1B and neoplasm: Since TANs are composed of two subtype cells, antitumour N1 TANs (immunostimulator) and protumour N2 TANs (immunosuppressor) (Fridlender et al, 2009; Hofman, 2010; Mantovani, 2009), we compared the mRNA levels of selected cytokines, adhesion molecules and chemokines in TANs from B16F10-IL-1β tumours versus B16F10-vector tumours by quantitative RT-PCR (Fig 6E).