After screening four NPC cell lines for expression of key inflammasome components (Fig 3A), we chose HK1 cells for the in vitro analysis because the basal expression level of pro-IL-1β in this cell line is similar to that in NPC biopsies (Fig 1A), and inflammasome activation was easily measured without additional induction of the signal 1, pro-IL-1β. The gene discussed is IL1B; the disease is nasopharyngeal carcinoma.