Since both lymphoma and NPC are associated with EBV infection, we found that high levels of AIM2, RIG-I and NLRP3 inflammasome expression are significantly correlated with EBV infection in lymphoma cell lines (p = 0.043; Supporting Information Fig S12D), suggesting that EBV infection is a potential factor for AIM2, RIG-I and NLRP3 inflammasome overexpression in cancer cells of both epithelial and lymphocyte origin. Here, RIGI is linked to Epstein-Barr virus infection.