B16F10 cell-derived IL-1β significantly abolished tumour growth in wild-type syngeneic C57BL/6 mice and nude mice at days 29 and 36, respectively, although the tumour growth was similar during the first 3 weeks for B16F10-IL-1β, B16F10-pro-IL-1β and B16F10-vector cells (Fig 5B and Supporting Information Fig S10). Here, IL1B is linked to neoplasm.