Although rare variants of other genes such as RNASEL (Carpten et al. 2002), MSR1 (Xu et al. 2002), and ELAC2 (Tavtigian et al. 2001) have been previously identified in prostate cancer families and proposed as prostate cancer susceptibility alleles, follow-up studies have not supported their candidacy. The gene discussed is RNASEL; the disease is prostate cancer.