PTP4A3/PRL-3 mRNA was significantly correlated with virus infection (P = 0.0422), serum AFP (P = 0.0047), PIVKA-II (P = 0.0259), portal vein invasion (P = 0.0156), and vascular invasion (P = 0.0192) (Table 2). This evidence concerns the gene PTP4A3 and viral infectious disease.