PTP4A3 and hepatocellular carcinoma: Prenylation-dependent association could effectively block the function of PRL-3 in cell migration and invasion.8 Aberrant PTP4A3/PRL-3 expression may be closely related to poor tumor differentiation, tumor invasion, and poorer survival in HCC patients, and this accelerated hepatocarcinogenesis may be positively regulated by hepatoepithelial cell migration, thus promoting tumor progression and the establishment of the new vasculature needed for tumor survival and expansion.