CADM1 expression is significantly reduced in neuroblastoma and cancers of the lung, oesophagus and skin; furthermore, it is inversely correlated with cancer progression (Ito et al., 2003b; Nowacki et al., 2008; Uchino et al., 2003; You et al., 2010). The gene discussed is CADM1; the disease is neuroblastoma.