CADM1 and cancer: Since CADM1 is a tumour suppressor in several cell types (Fukuhara et al., 2002; Ito et al., 2003b; Kuramochi et al., 2001; Nowacki et al., 2008), this may predispose to various cancers and other diseases in which CADM1 is implicated, such as venous thrombosis (Hasstedt et al., 2009; Ito et al., 2003b; Nowacki et al., 2008; Uchino et al., 2003; You et al., 2010).