To put our research in perspective, a crucial comment to make is that except to greatly aid in explaining the occurrence of supramaximal elevation phenomena for hormones in general, we acknowledge that the prolactin data per se in our manuscript do not help in pertaining to ‘rule in’ or ‘rule out’ CHF using biomarkers in any patients, not even in anephric patients. The gene discussed is PRL; the disease is congestive heart failure.