NPPB and systolic heart failure: However, in contrast to our interpretation, using the recommended cut-off values of BNP <100ng/L and NT-proBNP <125ng/L for exclusion of CHF, Zuber et al.[9] have previously shown in 2009 that those chosen cut-off values fail to adequately ‘rule-out’ CHF in their 384 subject patients from a population with a high prevalence of CHF (50% with systolic heart failure and 8% with isolated diastolic heart failure).