The univariate analyses revealed 16 variables - diabetes, hematocrit, lactate, serum albumin, brain natriuretic peptide, creatine kinase-MB, GV parameters (SD of mean BG, coefficient of variation, Hermanides' metric), SAPS II, insulin therapy, vasopressor, mechanical ventilation, renal replacement therapy, hepatic failure, and ventilator-associated pneumonia - that were significantly associated with hypoglycemic events (P < 0.05). The gene discussed is INS; the disease is Hepatic failure.