In cell culture experiments where LPP1 expression has been manipulated, LPP1 has been shown to be important for the attenuation of several atherothrombogenic and malignant processes induced by LPA, including platelet aggregation[25], the release of the proinflammatory cytokine IL-8[22], and ovarian cancer cell proliferation[32]. This evidence concerns the gene PLPP1 and ovarian carcinoma.