The antibodies to P. gingivalis have been reported to be more frequent in RA subjects compared with controls and that the titer of RA-related autoantibodies and C-reactive protein concentrations are also higher in individuals infected with P. gingivalis suggesting that this organism plays a role in disease risk and progression in RA (Mikuls et al., 2009). The gene discussed is CRP; the disease is rheumatoid arthritis.