Epidermal growth factor receptors (EGFR) suppress the tumor suppressors miR-143 and miR-145, which coordinately control multiple targets of downstream cell-signaling pathways (i.e., K-Ras or MYC, cdk6, E2F3, and G1/S-specific cyclin-D2 or CCND2) in the AOM rodent model (Zhu et al., 2011). This evidence concerns the gene CCND2 and infectious otitis media.