Tumor-suppressor miR-16 (downregulated in some cancers) and miR-132 (which is methylation-silenced in prostate cancer) have been identified as putative endogenous modulators of neuronal tau phosphorylation and tau exon 10 splicing, respectively (Bottoni et al., 2005; Hébert et al., 2010; Formosa et al., 2012; Rivas et al., 2012). The gene discussed is MAPT; the disease is cancer.