Since neuronal outgrowth requires the involvement of TDP-43 in miRNA biogenesis, aberrant forms of TDP-43 that precipitate in the cytoplasm may trigger events leading to the motor neuron degeneration that characterizes ALS (Kawahara, 2010; Kawahara and Mieda-Sato, 2012). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.