Since neuronal outgrowth requires the involvement of TDP-43 in miRNA biogenesis, aberrant forms of TDP-43 that precipitate in the cytoplasm may trigger events leading to the motor neuron degeneration that characterizes ALS (Kawahara, 2010; Kawahara and Mieda-Sato, 2012). Here, TARDBP is linked to Motor neuron atrophy.