However, CD4+ T cell infiltration of ocular tumors does not appear to be compromised as Ad5E1 tumors are spontaneously rejected when placed in the a.c. by a process that requires CD4+ T cells, macrophages, and IFNγ (Schurmans et al., 2001; Wang et al., 2003; Boonman et al., 2006; Dace et al., 2008). The gene discussed is IFNG; the disease is eye neoplasm.