Moreover, while hBD-1 and hBD-2 were found to recruit memory T cells and immature DC via the GPCR CCR6 (Yang et al., 1999), and while hBD-3 can mobilize cells expressing CCR6 in vitro (Rohrl et al., 2008), it does not appear to be the case in vivo, since hBD-3 exclusively recruits CCR2 expressing myeloid cells at the exclusion of lymphoid cells into oral CIS lesions (Jin et al., 2010). Here, CCR6 is linked to in situ carcinoma.