To further elucidate the role of tumor cell-produced hBD-3 in oral tumorigenesis, Jin et al. (2010) have shown that tumor cells in oral CIS lesions produce hBD-3, but not macrophage chemotactic protein-1 (MCP-1/CCL2), a known chemokine for macrophage migration, and that hBD-3 chemoattracts monocytes/macrophages. This evidence concerns the gene CCL2 and neoplasm.