Furthermore, in addition to inducing dendritic cell maturation (Biragyn et al., 2002) through toll-like receptor 4 (TLR4), murine beta defensin-2 (mBD-2)-based vaccines are proposed to elicit potent cell mediated responses and antitumor immunity (Biragyn et al., 2002; see β-Defensins in Cancer). Here, TLR4 is linked to cancer.