TRPV1 and congestive heart failure: Recently, we (Wang et al., 2010a) further demonstrated that (1) the response of group IV afferents to exogenous TRPV1 activation by capsaicin was blunted in CHF rats and (2) protein expression of TRPV1 receptors in the DRG was significantly decreased in C-fiber DRG neurons of CHF rats.