Conduction of depolarization throughout the heart also appears dependent on caveolins, as Cav-3 KO animals display disorganization of the T-tubule complex (Galbiati et al., 2001), and mutations in the Cav-3 gene have been identified in patients with congenital long-QT syndrome (Vatta et al., 2006). The gene discussed is CAV3; the disease is Prolonged QT interval.