A neuroprotective role for Cav-1 was first demonstrated in Cav-1 KO mice, which had a larger cerebral infarct size in response to ischemia (Jasmin et al., 2007) that may have been due to alterations in the permeability of the blood brain barrier (Gu et al., 2012) secondary to Cav-1 related translocation of the tight-junction protein claudin-5 (Liu et al., 2012). This evidence concerns the gene CAV1 and cerebral infarction.