POSTN and neoplasm: Judging by early activation markers like periostin, one can observe in pancreatic diseases that the initial activation of quiescent PSC and extracellular matrix (ECM) deposition takes place in the periacinar spaces (Erkan et al., 2009, 2012c).This type of CP-like changes surround the tumor like an umbra and infiltrate the normal parenchyma (Figures 1C,D).