However, as a proof of principle, Von Hoff et al. used in a Phase I/II trial nanoparticle albumin-bound (nab) paclitaxel (to deplete the stoma in PDAC) alone and in combination with gemcitabine and showed that through depletion of stroma, higher concentrations of gemcitabine can be delivered in the tumor (Von Hoff et al., 2011). The gene discussed is ALB; the disease is neoplasm.