The JNK ⊣ ERK/p38 crosstalk may involve a p53-DUSP2 dependent pathway, as the c-Jun mediated inhibition of p38 observed in hepatocytes was p53 dependent (Stepniak et al., 2006) and DUSP2 was identified as a transcriptional target of p53 in mouse embryonic fibroblast and breast cancer cell lines (Yin et al., 2003). The gene discussed is MAPK8; the disease is breast carcinoma.