Further, DUSP2 was shown to dephosphorylate ERK and p38 in NIH3T3 and HeLa cells (Chu et al., 1996) and was implicated in the inactivation of ERK2 during p53 dependent apoptosis in breast and colon cancer cell lines (Yin et al., 2003; Dickinson and Keyse, 2006). This evidence concerns the gene TP53 and malignant colon neoplasm.