Together, these data indicate that the DUSP4/16 mediated ERK-JNK crosstalk is conserved between cell lines (epithelial, fibroblast, immune, and cancer cells) based on which the dynamic model features ERK induced mRNA and protein expression of DUSP4/16 that catalyze the dephosphorylation of JNK. This evidence concerns the gene MAPK1 and cancer.