MAPK8 and cancer: Indeed, forced expression of DUSP2 abolished hypoxia induced chemoresistance in human cancer cell lines (Lin et al., 2011), and inhibition of DUSP1 sensitized several resistant cancer cell lines to JNK dependent apoptosis (Laderoute et al., 1999; Sánchez-Pérez et al., 2000; Small et al., 2007; Wang et al., 2008).