CFTR and cystic fibrosis: Soon after, by studying the ΔF508-CFTR activity and the trafficking by immunofluorescence in freshly isolated native airway epithelial cells from CF patients, the authors realized that treatment of cells with MPB-07 caused dramatic relocation of ΔF508-CFTR to the apical region such that the majority of CF cells showed a pattern similar to that of non-CF cells (Dormer et al., 2001).