ADCYAP1 and schizophrenia: For instance, increased locomotor activity displayed by PACAP KO mice is considered to be schizophrenia-like behavior in rodents, because psychostimulants induce schizophrenic-like symptoms in healthy individuals and increase locomotor activity in rodents (Tsai and Coyle, 2002; Chen et al., 2006; Powell and Miyakawa, 2006).