In the Amyg, alterations in CREB-mediated signaling following alcohol exposure has been implicated in anxiety associated with alcohol withdrawal, albeit in a direction opposite of that in the Acb (Pandey et al., 2005); however, the time-points of CREB evaluation in the Amyg (although during acute withdrawal) were more protracted than in other investigations (24 h vs. 6–10 h into withdrawal; (Pandey et al., 2005; Williams et al., 2012, respectively). This evidence concerns the gene CREB1 and Anxiety.