The MitoQ10-mediated decrease in AMPK activity was greater in HSVECs from CAD patients with T2D (0.056±0.004 compared with 0.009±0.01 nmol·min−1·mg−1; P=0.02; Figure 5B) than in those from patients with CAD alone (0.035±0.005 compared with 0.014±0.0002 nmol·min−1·mg−1; P=0.06; Figure 5A). Here, PRKAA1 is linked to type 2 diabetes mellitus.