RASD1 and breast carcinoma: The down-regulation of RASD1 (RAS, dexamethasone-induced 1), a potential miR-375 target that negatively regulates ER alpha expression in breast cancer further confirms that the genes involved in the estrogen receptor regulated pathways could be under permanent transcriptional modification as a manifestation of a higher degree of cell differentiation of the parous breast, in spite of the lack of transcriptomic differences in the levels of the receptor between parous and nulliparous breast tissues.