For example, genes involved in trafficking and activation of macrophages, natural killer (NK) cells, and dendritic cells (DC) (CCR2, CCL19/CCR7, CCL3, CCL2, Csf3), promotion of cellular responses (CD68, TNFα, IL-10, CCL3, GITR, IL-6, IL-1α, IL-1β, IL-12p35), and innate responses to bacterial infection (C3, CD40, Gusb, Nos2) were upregulated with Hb infection and downregulated with anti-IL-7Rα M595 treatment in a dose-dependent manner (Figure 3A). The gene discussed is CD40; the disease is bacterial infectious disease.