Representative H&E-stained sections of proximal colon from uninfected control mice (isotype broth), and Hb-infected mice treated with isotype control or anti-IL-7Rα M595 are shown in Figure 6C. Hb-induced disease in Rag2−/− mice was less severe than that in Mdr1a−/− mice and was characterized by moderate hyperplastic and lymphohistiocytic colitis with elongation of colonic glands and expansion of lamina propria and submucosa with inflammatory cells (isotype Hb). This evidence concerns the gene IL7R and colitis.