TIMP1 and Ureteral obstruction: Experiment on unilateral ureteral obstruction model based on TIMP-1 transgenic mice found that the expression of TIMP-1 was upregulated, gelatinase activity was downregulated, ICAM-1 and TGF, collagenIand III were upregulated, renal interstitial fibrosis and macrophage infiltration aggravated, which suggest that TIMP-1 over expression might paiticipate in renal interstitial fibrosis and involve in the course of inflammatory reaction[7].