Wagrowska- Danilewicz et al[8] found that the expression of both MMP-2 and TIMP-1 were upregulated in reanal allografts of 17 chronic allograft nephropathy patients compared to renal tissue of 11 normal controls, which suggest the remodeling of impaired renal structure have correlation with the regulation imbalance of MMP-2 and TIMP-1. Here, TIMP1 is linked to Crouzon syndrome-acanthosis nigricans syndrome.