In the last three years, with whole-genome sequencing approaches, several novel mutations have been identified in genes involved in epigenetic (IDH1 and 2-isocitrate dehydrogenases; TET2-tet methylcytosine dioxygenase 2; DNMT3—DNA (cytosine-5-)-methyltransferase 3 alpha) and posttranscription regulation (miR-155, miR-29, and miR-146), pointing to the complex nature of AML [25]. This evidence concerns the gene TET2 and acute myeloid leukemia.