Different myeloid malignancies, including AML, share the same alterations in genes like IDH1, IDH2, ASXL1 (additional sex combs like 1), EZH2 (enhancer of zeste homolog 2 gene), RUNX1, DNMT3A, TET2, p53, and CBL (Casitas B-cell lymphoma gene), although unlike the JAK2V617F mutation, none of these markers can alone define diagnosis for any specific myeloid entity. The gene discussed is RUNX1; the disease is acute myeloid leukemia.