Different myeloid malignancies, including AML, share the same alterations in genes like IDH1, IDH2, ASXL1 (additional sex combs like 1), EZH2 (enhancer of zeste homolog 2 gene), RUNX1, DNMT3A, TET2, p53, and CBL (Casitas B-cell lymphoma gene), although unlike the JAK2V617F mutation, none of these markers can alone define diagnosis for any specific myeloid entity. This evidence concerns the gene TET2 and acute myeloid leukemia.