CYLD (the familial cylindromatosis tumor suppressor gene) enhances the activation of the transcription factor NFkapa-B [23], RBBP6, (which binds to the retinoblastoma gene product pRB) [24], and PNUTL2 (which is an apoptosis-related protein in the TGF-beta signaling pathway) [25]. The gene discussed is RB1; the disease is neoplasm.