GCG and neoplasm: These GLP-1 upregulated, proliferation-related genes include: the prolactin receptor, which has been proposed to regulate islet mass expansion during pregnancy [14]; retinoblastoma binding protein-6 (RBBP6) is a multifunctional protein found ostensibly in all eukaryotes but not in bacteria, which is implicated in a diverse set of cellular functions including mRNA metabolism, regulation of the cell cycle, tumour igenesis and development.