In order to know how the IFC-305 repairs the proliferative function in the cirrhotic liver, we studied the role of cyclins of the cellular cycle (cyclins D, E, A, and B), cyclin-dependent kinase (CDKs), some other proteins such as PCNA, pRb, E2F1, p53, and the hepatic growth factor (HGF) and correlated them with some parameters of the mitochondrial function in experimental cirrhosis induced by CCl4. The gene discussed is PCNA; the disease is Cirrhosis.