Indeed, caspase-1 cleaved the haploinsufficient tumor suppressor Beclin-1 that was also upregulated by H11/HspB8 through a TAK1/mTORC1 pathway that involved mTOR phosphorylation at S2481, which is the site of intrinsic mTORC1-specific catalytic activity [64]. The gene discussed is HSPB8; the disease is neoplasm.