In glioblastoma cells, H11/HspB8 expression is inversely correlated to Sam68, thereby increasing the S phase population and the expression of cell-cycle regulatory proteins such as cyclins E and A, ribonucleotide reductase, and proliferating cell nuclear antigen (PCNA), which are required for the transition from the G1 to the S phase of the cell-cycle [55]. This evidence concerns the gene H1-1 and glioblastoma.