The cleaved Beclin-1 fragment translocated to the mitochondria and contributed to apoptosis, but the pronounced upregulation of Beclin-1 in A2058 xenografts, which have lower levels of H11/HspB8-induced apoptosis than their A375 counterparts, suggests that Beclin-1 also contributes to tumor growth inhibition through still unrecognized tumor suppressor functions (Figure 3(c)). This evidence concerns the gene HSPB8 and neoplasm.