Haplotypic analyses of both G-350A and C825T GNB3 variants based on unrelated participants (Table 6) indicated that the haplotype T825/G-350 might be associated with the odds of essential hypertension (OR = 0.586, 95%  CI = 0.358–0.958), although the alternative hypothesis of a better fit for the alternative model (e.g., a model with significant haplotypic effects) failed to be accepted (P = 0.152). Here, GNB3 is linked to essential hypertension.