Licensed biological agents, such as tumor necrosis factor (TNF)-α inhibitors, the costimulatory molecule inhibitor (abatacept), the B-cell depletion agent (rituximab), and the interleukin-6 receptor inhibitor (tocilizumab), have greatly enhanced effective RA treatment and improved health outcomes [4], [5], [6]. Here, TNF is linked to rheumatoid arthritis.