Although the majority (85%, 44/52) of apocrine-eccrine carcinomas in our series demonstrated EGFR protein overexpression, only EGFR trisomy or polysomy (13/47, 28%) and no gene amplification were documented by FISH, most frequently noted in eccrine carcinoma, hidradenocarcinoma and porocarcinoma. This evidence concerns the gene EGFR and hidradenocarcinoma.