TP53 mutations were detected in 2 eccrine carcinomas (c.743G>A; p.Arg248Gln and c.817C>T; p.Arg273Cys), 2 hidradenocarcinomas (c.817C>T; p.Arg273Cys), 2 aggressive digital papillary adenocarcinoma (c.818G>A; p.Arg273His and c.817C>T; p.Arg273Cys), and 1 malignant cylindroma (c.818G>A; p.Arg273His). Here, TP53 is linked to eccrine carcinoma.