We have been studying formulated 3,3′-Diindolylmethane (B-DIM) and showed that B-DIM can induce apoptosis and inhibit cell growth, angiogenesis, and invasion of prostate cancer cells by regulating NF-κB, Akt and AR signaling pathways [24]–[25]. Here, AKT1 is linked to Familial prostate cancer.