CASP3 and neuroblastoma: Whereas PIK75 treatment led to enhanced PARP and pro-caspase 3 cleavage in LAN1 and SH-SY5Y cells (Fig. 9A+B) or to an increase in the caspase 3/7 activity in WAC2 NB cells (Fig. 9C), a comparable induction of apoptosis could not be observed with R1507 treatment in NB cells or by treating the MB cell line PFSK (Fig. 9A+B).