EGF and neoplasm: Indeed, polypeptide growth factors such as insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), neuregulins and neurotrophins have been shown to control embryonal tumor proliferation, survival, differentiation and metastasis [11]–[15] by binding to specific receptor tyrosine kinases (RTKs).