In a population of 11,773 patients from 26 independent studies, we found that the risk of mortality in colorectal cancer patients harboring BRAF-V600E mutation is more than two times higher than those with wild-type BRAF. We also demonstrated that melanoma patients with BRAF mutation have a 1.7 times higher risk of mortality when compared with their counterparts without BRAF mutation in a population of 674 patients from the pooled result of 4 studies. Here, BRAF is linked to melanoma.