CCN1 and osteosarcoma: For example, CYR61 expression is down-regulated in cervical cancer [30], lung cancer [31]–[33], endometrial cancer [34] and hepatocellular carcinoma [35]; however, its up-regulation has been reported in multiple tumor types, including osteosarcoma [36], glioma [37], [38], and breast cancer [39], [40].