For example, decreased CTGF expression has been reported in lung cancer [31], breast cancer [40], Wilm’s tumor [41] and ovarian cancer [42]; while increased expression was found in papillary thyroid cancer [43], colorectal cancer [44], head and neck squamous cell carcinoma [45], [46] and glioblastoma [47]. This evidence concerns the gene CCN2 and head and neck squamous cell carcinoma.