Initially, it was proposed that activation of mTOR signaling in the hypothalamus promoted anorexia; in fact it was demonstrated that short-term central administration of anorectic factors, such as leucine, leptin, CNTF, α-lipoic acid or BMP7 increase hypothalamic mTOR signaling [20], [22], [23], [26], [29], [40]. Here, LEP is linked to Anorexia.