The AUC value of ApoAII-2+ApoCIII0 for stage I pancreatic cancer (0.868) was higher than that of CA19-9 (0.774) (Table S5), suggesting the potential advantage of ApoAII-2+ApoCIII0 over CA19-9 for detection of early-stage pancreatic cancer. Here, APOA2 is linked to familial pancreatic carcinoma.