ApoAII-2 and ApoCIII-0 were able to differentiate the 103 pancreatic cancer patients from the 112 healthy controls (Cohort 1) with an area-under-curve (AUC) value of 0.877 and 0.798, respectively (Fig. 4A and Table S3). This evidence concerns the gene APOC3 and familial pancreatic carcinoma.